Biocompatible and Biodegradable Anionic Hydrogel System

Description:

Technology # 18-18

 

An Anionic Hydrogel product/technology

 

The development of bio-compatible and bio-degradable hydrogels for sustained delivery of biological therapeutic agents is important for many regenerative medicine applications. In general, hydrogels can be made from both natural and synthetic polymers. Natural polymers are often bio-compatible and biodegradable, but are difficult to be chemically functionalized for sustained release and/or potentially immunogenic in the host body. Hydrogels made from synthetic polymers have several advantages including modifiable chemical properties, tunable mechanical properties, controllable porosity and transport properties. Poly(ethylene glycol) (PEG) is a material commonly used to form synthetic hydrogels due to its excellent bio-compatibility, but PEG hydrogels typically possess minimal or no intrinsic biological activity that limits their use for sustained release of proteins.

However, a new invention has been created to synthesize bio-compatible and biodegradable anionic hydrogels for protein delivery. The advantages to this method are vast including: a simple two-step process, the raw materials used are inexpensive, reaction protocol can be scaled up to match the industrial production requirement, the hydrogel contains more than 92% water suggesting that it is more environmentally friendly in comparison to other commercially available products, the hydrogels can be easily engineered into different forms to be used as patches or injectable gels, the hydrogels are capable of loading positively charged proteins and promote sustained release of proteins.

 

Application(s):

 

Wound Filler; Wound Dressing; Hydro Gel; 

Wound healing; tissue regeneration; drug delivery system; humidity sensing; 

 

Advantage(s):

 

* This hydrogel was synthesized in one pot and only a two-step procedure was involved. The raw materials used are inexpensive and the reaction protocol can be scaled up to match the industrial production requirement.

 

* This injectable hydrogel contains more than 92% of water, which is much higher than other commercially-available products such as 3 M Tegaderm Hydrogel Wound Filler (80% water content), suggesting that it is more environmentally friendly in addition to the biocompatibility and biodegradability.

 

* These hydrogels are capable of loading positively charged protein and promote sustained release of protein.

 

 

Technology:

 

Bio-compatible and bio-degradable hydrogels for sustained delivery of biological therapeutic agents is important for many regenerative medicine applications

 

____________________________________________ 

This invention/technology is available for licensing.

For interested parties seeking further information, feel free to contact:

Mark Allen Lanoue

Technology Manager / Tech Ventures

University of Arkansas

(479) 575-7243

malanoue@uark.edu

 

Patent Information:
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Provisional United States 62/670,578 5/11/2018    
For Information, Contact:
Mark Lanoue
Technology Manager
University of Arkansas
479-575-7243
malanoue@uark.edu
Inventors:
Jingyi Chen
Tengjiao Wang
Isabelle Niyonshuti
Suresh Thallapuranam
Ravi Kumar Gundampati
Shilipi Agarwal
Kyle Quinn
Jake Jones
Keywords:
© 2020. All Rights Reserved. Powered by Inteum