Macrocyclic ligands containing multiple N-heterocyclic carbenes for transition metal catalysts


N-Heterocyclic Carbonates (NHC’s) are widely used as supports for catalysts and pre-catalysts for both homogeneous and heterogeneous catalysis. These supporting ligands have been shown to be successful to support catalysts for a variety of organic transformations.  However, new ligands have been developed that are superior to the existing well-known NHC’s.

The new ligands are polydentate, meaning that they have multiple “teeth” with which to attach to a transition metal center.  Because these ligands attach to a metal atom in more than one place, they are less likely to fall off the metal center and therefore form more stable compounds.  The stability of the new ligands is such that they exist under a variety of reaction conditions and temperatures.  In catalysts, polydentate ligands lead to more stable catalysts that remain reactive for a larger number of chemical processes.  Reactions including hydrogenation, C-C, C-N, and C-H coupling reactions have a particular applicability for this ligand class.

These compounds have been shown to be effective for organic transformations and have the potential for applications in a variety of applications in a variety of reactions.  Additionally, they represent a new entry in NHC chemistry with a variety of steric and electronic environments that have not been previously accessed.


The new ligands are patent pending and are available for license.

For interested parties seeking further information, feel free to contact:


Mark Lanoue

(479) 575-7243


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Patent Information:
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
Provisional United States 62/547,253 8/18/2017    
For Information, Contact:
Mark Lanoue
Technology Manager
University of Arkansas
Stefan Kilyanek
Rajesh Thapa
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