Safer Treatment for Difficult Blood Clots


A thrombus is a mass that clogs a blood vessel in the body and cuts off the flow of blood.  A loss of blood flow to any part of the body can cause damage, and a loss of blood to the brain or heart is especially serious.


If the patient can receive medical attention within three hours of the symptoms, doctors can administer a throbolytic agent such as a tissue plasminogen activator (tPA), which will dissolve the clot.  Certain kinds of blood clots, those that are older and contain fibrous materials, can be difficult to dissolve even with the use of tPA.  To treat these more difficult cases, sonothrombolysis (ultrasound) can be used in combination with tPA.  However, tPA can also increase the risk of intracranial hemorrhage.


An alternative method of treating these difficult clots has been invented that works as well with the sonothrombolysis as the tPA.  The new method uses biodegradable starch nanoparticles with  sonothrombolysis to attack the thrombus.  The results from animal testing have shown that the use of the starch nanoparticles to abrade the thrombus works as well as the use of tPA, thus making a safer treatment for difficult blood clots.


The new treatment is patent pending and is available for license.  To see and read the publication of the patent application, click the following link




Patent Information:
App Type Country Serial No. Patent No. File Date Issued Date Expire Date
PCT United States PCT/US2013/061396 9/24/2013    
For Information, Contact:
Mark Swaney
Technology Licensing Officer
University of Arkansas
Ajay Prabhakar Malshe
Michael Borelli
Eric Hamilton
Kaleb Smithson
Dheeraj Ahluwalia
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